We observed an increase in FoxO3a phosphorylation in WT and Akt1−/− mice concomitant with tumor burden (Figure 6M, panels 1 and 2), but FoxO3a phosphorylation remained constant in Akt2 and Akt3 mice irrespective of tumor burden (Figure 6M, panels 3 and 4). This evidence concerns the gene FOXO3 and neoplasm.