Phospho-mTOR levels increased in conjunction with increased tumor burden in Akt1−/− and Akt3−/− mice (Figure 6J, panels 2 and 4), remained constant in Akt2−/− mice (Figure 6J, panel 3) and tapered off in WT mice with late stage tumors (Figure 6J, panel 1). Here, MTOR is linked to neoplasm.