Interestingly, neither Akt1−/− nor Akt3−/− mice had detectable levels of phosphorylated pGSK-3α/β (Figure 6G, panels 2 and 4, respectively) whereas Akt2−/− mice showed a decrease in pGSK-3α/β phosphorylation as tumor burden increased (Figure 6G, panel 3). The gene discussed is AKT3; the disease is neoplasm.