MAPT and Parkinson disease: Association of Tau pathology with synucleinopathies was also found by Duka et al., who demonstrated the ASN-mediated hyperphosphorylation of Tau at Ser396/404 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinsonism [31].