To better understand the molecular bases of ACDMPV and to identify major genes and pathways involved in lung development, we performed comparative analyses of lung transcriptomes in patients with ACDMPV and in Foxf1+/− mice using Human Ref-8 v3 and Mouse WG-6 v2 Expression BeadChip Illumina microarrays, respectively. The gene discussed is FOXF1; the disease is alveolar capillary dysplasia with misalignment of pulmonary veins.