Similarly, Theodorescu and colleagues have shown the expression of RhoGDI2 in the T24 human bladder cancer cell line, but not in the more aggressive T24T lineage, and that forced expression of RhoGDI2 in highly aggressive T24T cells suppresses cancer cell invasion, motility, and lung metastasis [41, 7]. This evidence concerns the gene ARHGDIB and urinary bladder cancer.