To determine whether upregulation of Snail expression is required for RhoGDI2-induced chemoresistance in gastric cancer cells, we used various chemotherapeutic drugs such as cisplatin, etoposide, staurosporin, 5-fluorouracil, paclitaxel, and doxorubicin to treat Snail-depleted RhoGDI2-overexpressing gastric cancer cells. This evidence concerns the gene SNAI1 and gastric cancer.