TCHP and epidermolytic ichthyosis: We performed known and predicted protein–protein interaction analysis using the STRING database ( http://www.string-db.org/)31 to look for functional protein associations with Krt76. There are no experimentally recorded interactions of Krt76, but predicted interactions retrieved other keratins or intermediate filament-associated proteins such as Tchp, Krt77, Krt86 and Krt10. Numerous genetic skin disorders are associated with keratin mutations, including Krt10, which is mutated in recessive epidermolytic ichthyosis with hyperkeratosis32 (Fig. 4i).