Moreover, c-kit silencing efficiently decreased the level of phosphorylated Smad2 and the expression of TGF-β1 and TGF-β2 mRNAs in c-kit-expressing ACC-M cells (Figure 5C, D); whereas knockdown of c-kit upregulated E-cadherin expression and downregulated N-cadherin expression. Here, CDH2 is linked to adrenal cortex carcinoma.