At mitochondria, vMIA blocks Bax-mediated permeabilization of the OMM [17,18,30,31], reduces ATP synthesis [28,29,32], causes mitochondrial fragmentation [12,30,33,34], and controls HtrA2/Omi-induced cell death through very late times of HCMV infection [35]. Here, HTRA2 is linked to cytomegalovirus infection.