CCN2 and neoplasm: 6e). In recent years, TAMs have attracted attention as therapeutic targets for solid tumors. Tumor-secreted factors that induce macrophage infiltration and regulate the functions of TAMs also deserve consideration. CTGF, another member of the CCN family associated with tumorigenesis, is a novel therapeutic target for the treatment of pancreatic cancer, and is currently being investigated in a Phase I clinical trial [41, 42].