5). Similarly, we found that injection of PC3 and RAW264.7 cells into SCID mice induced rapid tumor growth and angiogenesis, but this was markedly reduced by knockdown of CCN3 expression in PC3 cells (fig. 6a-d). Our results also showed that CCN3 expression was correlated with CD206+ M2 macrophage infiltration in xenograft mice model (fig. 6d). This evidence concerns the gene MRC1 and neoplasm.