Furthermore, there was no difference in BMD between women with type 2 diabetes treated with diet, oral antidiabetics or insulin therapy, but BMD was lower in men with type 2 diabetes undergoing insulin treatment (LSMEAN ± SE; FN-BMD 0.86 ± 0.02 g/cm2; LS-BMD 1.035 ± 0.02 g/cm2) compared with those treated with other therapies (FN-BMD 0.91 ± 0.02 g/cm2; LS-BMD 1.13 ± 0.02 g/cm2) (p = 0.02; p = 0.004). The gene discussed is INS; the disease is type 2 diabetes mellitus.