New evidence concerning FeNO in relation to COPD and the best-recognized comorbidities collectively highlights the following potential roles of this biomarker in monitoring (1) the stability of COPD; (2) the response to therapy in heart failure and in PAH patients; (3) the possible progression to COPD of other diseases like alpha-1 antitrypsin deficiency and psoriasis. The gene discussed is PSMA6; the disease is heart failure.