Our study found that plasma ADPN level inversely correlates with GFR, some metabolic and inflammatory factors such as BMI, CRP, FBS, and HDL-cholesterol levels in CKD patients not in dialysis patients, but it was not associated with other important metabolic syndrome determinants such as total cholesterol, triglyceride, LDL-cholesterol, and other inflammatory markers such as ESR, albumin, and hemoglobin levels in these patients. The gene discussed is ESR1; the disease is chronic kidney disease.