So we evaluated the cyclin and CDK expressions which control the cancer cell cycle aberrant activation of cyclin D1-Cdk4 signaling pathway is commonly found in pancreatic ductal adenocarcinoma, the increased expression of cyclin D1 and CDK4 leads to the activation of cyclin D1-Cdk4 signaling and unchecked proliferation, and cyclin D1 is also the target gene of Wnt/β-catenin cell signaling which is known to promote the neoplastic transformation in PDA [16]. The gene discussed is CDK4; the disease is cancer.