Eleven of these 16 loci were found to be significantly associated with the risk of T2D, including loci in TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC20A8, JAZF1, and HHEX [51]. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.