INS and type 2 diabetes mellitus: GWAS analysis of fasting glucose concentrations conducted by the meta-analyses of glucose and insulin-related traits consortium (MAGIC) also demonstrated association of adenylate cyclase-5 (ADCY5), prospero-related homeobox-1 (PROX1), glucokinase (GCK), glucokinase regulatory protein (GCKR), and diacylglycerol kinase (DGKB) transmembrane protein-195 (TMEM195) with T2D [14].