Another study using meta-analysis of T2D data found further T2D-associated variants in loci harboring genes including juxtaposed with another zinc finger gene 1 (JAZF1), cell division cycle 123, calcium/calmodulin-dependent protein kinase 1D (CDC123, CAMK1D), tetraspanin 8, leucine-rich repeat-containing G protein-coupled receptor 5 (TSPAN8, LGR5), thyroid adenoma associated thyroid adenoma associated (THADA), ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), and notch gene homolog 2 (NOTCH2) [25]. The gene discussed is LGR5; the disease is type 2 diabetes mellitus.