Eleven of these 16 loci were found to be significantly associated with the risk of T2D, including loci in TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC20A8, JAZF1, and HHEX [51]. Here, NOTCH2 is linked to type 2 diabetes mellitus.