HDAC4 and amyotrophic lateral sclerosis: With our finding that TDP-43 overexpression increases protein levels of the miR-1/miR-206 target, HDAC4, whose dysregulation correlates with ALS disease progression (15), further interrogation of TDP-43 levels, localization, and activity in skeletal muscle of individuals with ALS at various stages of the disease seems warranted.