PRKN and Parkinson disease: The most commonly occurring PD-causing mutations are in the mitochondria-associated genes encoding Parkin (PARK2), PINK1 (PARK6) and DJ-1 (PARK7) (Lesage and Brice, 2009; Schapira and Tolosa, 2010; Martin et al., 2011; Klein and Westenberger, 2012).