Although an earlier report suggested that HSPB1 overexpression led to a small delay of Htt toxicity in rats (Perrin et al., 2007), studies in a mouse model for HD (Zourlidou et al., 2007) as well as several studies in cells (Fig. 2) showed that HSPB1 is rather inefficient in delaying polyQ aggregation. Here, HSPB1 is linked to Huntington disease.