We have previously shown that the T-allele of the FSHB -211G/T promoter variant (rs10835638) was associated with significantly reduced serum FSH levels and total testes volume in the Baltic cohort of young men [6], [7], and these results were confirmed in Estonian, Italian and German infertile male patients [8]–[10]. The gene discussed is BRD2; the disease is Infertility.