Univariate Cox regression analyses showed a significant poorer overall survival in patients with high level of serum AFP (HR, 1.63; 95% CI, 1.31–2.03, P<0.0001), in patients with larger size of tumor (HR, 2.53; 95% CI, 1.96–3.27; P<0.0001), in patients with multiple lesions (HR, 1.40; 95% CI, 1.12–1.75; P = 0.003), in patients with higher degree of BCLC stage (HR, 2.18; 95% CI, 1.75–2.71, P<0.0001), and in patients with existence of PVTT (HR, 2.43; 95% CI, 1.93–3.05; P<0.0001) when compared with corresponding control patients groups. Here, AFP is linked to neoplasm.