AFP and neoplasm: Furthermore, in multivariate Cox regression analysis, significantly increased death risk was still observed in patients with high level of serum AFP (HR, 1.35; 95% CI, 1.08–1.70; P = 0.010), in patients with large size of tumor (HR,1.95; 95% CI 1.46–2.61, P<0.0001), in patients with existence of PVTT(HR, 1.82; 95% CI 1.42–2.33, P<0.0001) and in patients with high BCLC stage (HR, 1.54; 95% CI 1.20–1.98, P = 0.001).