A series studies have reported that EPCAM promotes tumor formation and metastasis either by disrupting the link between a-catenin and F-actin [24] or acting as a signal transducer after sequential cleavage by tumor necrosis-factor alpha-converting enzyme (TACE/ADAM17) and a gamma-secretase complex containing presenilin 2 (PS-2) [25]. Here, EPCAM is linked to neoplasm.