We already demonstrated that cultured human ONH astrocytes respond with a strong increase of ECM protein secretion and produce high levels of the inhibitor of ECM degradation, PAI-1, when exposed to TGF-β2 [7]–[11], the most frequently increased aqueous humor (AH) factor in POAG patients [12], [13]. Here, TGFB2 is linked to open-angle glaucoma.