In sheer contrast to these, a number of ESCRT-I, -II, -III mutations, such as those mapping to Tsg101, vps28, Vps25, vps20, when made homozygous in eye discs, display a Mutant Eye No Eclosion (MENE) phenotype that have been associated loss of tumor suppression in Drosophila [30]. The gene discussed is VPS28; the disease is neoplasm.