To identify a gene expression ‘signature’ specific to these mice, principal component analysis (PCA) was used to compare the transcriptome of these tumours with those arising in other mouse models of pancreatic cancer, notably KPC,17, 18Pdx1-Cre, KrasG12D/+ Lkb1fl/+20 and Pdx1-Cre, KrasG12D/+ Apcfl/+ mice (figure 5D). The gene discussed is PDX1; the disease is familial pancreatic carcinoma.