Although not typically mutated in pancreatic cancer, Pten was highly mutated in two recent screens for gene mutations that accelerate KrasG12D-driven pancreatic tumorigenesis.13, 14 Additionally, we, and others, developed a mouse model in which pancreas specific deletion of one copy of PTEN, the negative regulator of mTOR, rapidly accelerated KrasG12D-driven PDAC.15, 16. Here, PTEN is linked to familial pancreatic carcinoma.