To further confirm that AGR2 is involved in DNP-mediated metastasis, 5–8F, an NPC cell line with high metastatic ability, was transfected with pUprosi-AGR2 (si-AGR2), and 5–8F-si-AGR2 was obtained by selection for G418 resistance. This evidence concerns the gene AGR2 and nasopharyngeal carcinoma.