High expression of RABEX-5 mRNA was found to significantly correlate with lymph node metastasis (P = 0.001), clinical stage (P = 0.004), preoperative prostate-specific antigen (P < 0.001), biochemical recurrence (P = 0.009), and Gleason score (P < 0.001). This evidence concerns the gene RABGEF1 and metastatic malignant neoplasm in the lymph nodes.