In this research, we first found RBP2 activation associated with VEGF expression and tumorgenesis and angiogenesis in human gastric cancer: RBP2 expression was positively associated with VEGF mRNA and protein expression and with MVD as identified by CD31 and CD34 antibody staining and cell proliferation by Ki67 overexpression, which suggests a link between RBP2 activation and VEGF overexpression. This evidence concerns the gene RBP2 and gastric cancer.