Particularly, in the Online Mendelian Inheritance in Man database – which collects known genetic lesions responsible for human inherited diseases – the following principal loci of osteoarthritis susceptibility (OS) and the associated polymorphisms, SNPs and aspartic acid (D) repeats, are reported: frizzled-related protein (FRZB) rs288326 (OS1A) and rs7775 (OS1B), MATN3 rs77245812 (OS2), ASPN D14 repeats (OS3), parathyroid hormone 2 (PTHR2) rs76758470 (OS4), growth and differentiation factor 5 (GDF5) rs143383 (OS5) and DVWA rs11718863 (OS6). Here, FRZB is linked to hereditary disease.