A multivariable analysis has additionally shown that the MGMT promoter methylation (MGMT-STP27) status and G-CIMP phenotype have a significant prognostic role in anaplastic oligodendrogliomas/oligoastrocytomas and are predictive of OS outcomes when treated with adjuvant procarbazine/CCNU/vincristine (PCV) (see below) chemotherapy (57). Here, MGMT is linked to anaplastic oligodendroglioma.