A positive CK20 and a negative CK7 would indicate an intestinal origin of the neoplasia with great accuracy because CK20 is usually expressed in the intestinal and gastric epithelium and the endocrine cells in the upper portions of the pyloric glands, whereas CK7 is usually found in the breast, lung, ovary, and urothelium [3–5, 11, 15]. Here, KRT20 is linked to neoplasm.