CD4 and Cryptococcal meningitis: This initial presentation was in keeping with the literature which highlights high baseline fungal burden (high blood or CSF CRAG), high fungal burden at end of amphotericin B induction treatment, low initial CD4 count, and early initiation of ART (less than 1-2 months from diagnosis of cryptococcal meningitis) as risk factors for cryptococcal IRIS [30–32].