This effect was found to be dependent on augmentation of tumor caspase-8 activity as well as on up-regulation of Fas and TNF related apoptosis-inducing ligand (TRAIL) receptor on tumor cells, thus inducing target apoptosis by NK cells through Fas/FasL and TRAIL/DR5 interactions (133–135). The gene discussed is TNFRSF10B; the disease is neoplasm.