Novel risk-associated SNP rs2208454 on chromosome 20p12 (Debette etal., 2010). This SNP is located in intron 3 of MACRO domain containing 2 (MACROD2) gene and in the downstream region of fibronectin leucine-rich transmembrane protein-3 (FLRT3) gene (Debette etal., 2010). These regions have been implicated in the regulation of growth factor signaling, angiogenesis, and neurogenesis, and ae associated with decreased risk of cerebral infarction seen on MRI. Here, FLRT3 is linked to brain infarction.