This interaction was further confirmed by immunofluorescence assay, by which we observed the co-localization of FXYD6 and Na+/K+-ATPase in the HCC tissues (Fig. S1), in HepG2 (Fig. 3B, upper panel) and in SMMC7721 transfectants of FXYD6 (Fig. 3B, lower panel). The gene discussed is FXYD6; the disease is hepatocellular carcinoma.