In addition, we have found that FXYD6 induces the expression of Na+/K+-ATPase α1 subunit (Fig. 3C and 3D), which may account for the up-regulation of Na+/K+-ATPase α1 in HCC tissues as described in the previous report (Xu et al., 2010). This evidence concerns the gene FXYD6 and hepatocellular carcinoma.