Kupelian et al.,20 in a recent non-interventional population-based study examining 2,301 men aged 30-79 years, and Gannagé-Yared,13 in a cross-sectional study on young men, reported an inverse association between the levels of SHBG and CRP, thus corroborating the inverse association between SHBG and insulin resistance. This evidence concerns the gene SHBG and Insulin resistance.