A significant negative association between SHBG levels and the prevalence of metabolic syndrome was found for patients in the second and third SHBG terciles, with a RR of metabolic syndrome of 0.60 for the second tercile (95% CI: 0.06 - 0.47) and 0.29 for the third tercile (95% CI: 0.16 - 0.54), in comparison with the first tercile (Table 2). This evidence concerns the gene SHBG and metabolic syndrome.