The SNP most significantly associated with CMH, rs6577641, is located in an intron of SATB1. SATB1 is a transcription factor and chromatin (re)organizer important for controlling the expression of many genes in a tissue or cell-type specific fashion, for instance in differentiating thymus T-cells [17] or differentiating skin keratinocytes [18]. Here, SATB1 is linked to hypertrophic cardiomyopathy 1.