Among all the identified proteins in plasma of RA patients, TTR was found to be associated with inflammation [24] and was validated in healthy controls and RA patients using Western blot analysis.The densitometric analysis of Western blots performed (Figure 2A) with plasma of severe RA patients (n = 12) showed 3.6 fold higher TTR levels in RA patients as compared to healthy control (n = 12). The gene discussed is TTR; the disease is rheumatoid arthritis.