In the present study, among all the identified proteins TTR autoantigen was found to be over expressed in the plasma, synovium and synovial fluid of RA patient.TTR protein has also been suggested as a possible biomarker in other diseases such as ovarian cancer [36], hepatocellular carcinoma [37], malnutrition [38] and mycosis fungoides [39]. This evidence concerns the gene TTR and hepatocellular carcinoma.