INS and type 2 diabetes mellitus: Among T2DM patients, only those in the CRMD group exhibited a decrease in glucose levels (p < 0.001 compared with the CRLFD group). Insulin and HbA1c levels decreased similarly in all three groups. The decrease in HOMA-IR was significantly greater in patients assigned to the CRMD compared with those assigned to the CRLFD (p = 0.04).