Determination of cholinesterase isozyme specificity (AChE versus butrylcholinesterase) and effects on amyloid-β aggregation for the sesquiterpene acetate [21,22], pyrrole derivative, PZT-compound, plastoquinones, and farnesylacetones classes of MM described in this article would provide an additional guide to development of novel compounds as therapies for Alzheimer’s disease. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.