Increased levels of TNF, IL-1, IL-6, IL-8, IFN-γ, IP-10, and CCL5 were observed in vivo and in vitro[11], [12], [13], and several cytokines, such as IFN-γ, IL-1α, IL-6, and TNF, were also detected in lung tissues of HPS cases [14]. This evidence concerns the gene TNF and Hermansky-Pudlak syndrome.