For example, MMP-9 can release factors such as vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1 and fibroblast growth factor (FGF)-2 sequestered in the extracellular matrix which stimulate tumour associated-endothelial cells and thus promote angiogenesis and tumor growth. This evidence concerns the gene FGF2 and neoplasm.