AFP and hepatocellular carcinoma: In both AFP+ and AFP− HCC subtypes, KIAA1114high cells generated increasing numbers of KIAA1114low cells until KIAA1114 expression reached steady-state levels (day 15), as shown by time-dependent decreases in the fluorescence intensities, suggesting the differentiation of KIAA1114high cells into KIAA1114low counterparts (Supplementary Figure 2).