MMP2 and Hepatic fibrosis: Similar to increased liver fibrosis in Mmp2−/− mice (Onozuka et al., 2011; Radbill et al., 2011), Takamiya and colleagues demonstrated increased collagen deposition and fibroblast activation – as indicated by αSMA production – in diabetic Mmp2−/− mice, supporting the view that MMP-2 has an anti-fibrotic role (Takamiya et al., 2013).