DISC1 and psychiatric disorder: However, other studies, including recent genome-wide association studies, have not identified Disc1 as a risk factor for psychiatric disorders (Zhang et al., 2005; Chen et al., 2007; Kim et al., 2008; Purcell et al., 2009; Mathieson et al., 2012) so although still of considerable interest in psychiatry, the role of Disc1 in such illnesses remains the subject of some debate (Sullivan, 2013).