Our main findings were as follows: (1) GI bleeding, a common manifestation for primary GISTs, was an independent predictor of worse prognosis for RFS; (2) the IHC underexpression of PTEN was associated with worse RFS at univariate analysis; (3) a Ki-67 LI >1% was associated with worse RFS at univariate analysis; (4) GI bleeding could be considered an additional prognostic indicator in the GIST risk classification scheme. The gene discussed is MKI67; the disease is gastrointestinal stromal tumor.