CASP8 and Miyoshi myopathy: Inhibition of proteasome promotes programmed cell death of MM cells, as bortezomib is a potent activator of three distinct apoptotic pathways: the intrinsic pathway mediated by caspase-9 activation, the extrinsic pathway mediated by caspase-8 and death receptors (DR) activation and thirdly, activation of ER stress response pathway that involves caspase-2 (Fig.4) [52–55].