GCs increase the activities of enzymes involved in fatty acid synthesis and promote the secretion of lipoproteins [114]; induce the hepatic gluconeogenic pathway [115]; promote the differentiation of preadipocytes to adipocytes, which could lead to an increased body fat mass [116]; inhibit an insulin-stimulated amino acid uptake by adipocytes [117]; and increase lipolysis or lipid oxidation which leads to the peripheral insulin resistance [118]. Here, INS is linked to Insulin resistance.