In addition, sesamol down-regulates the expressions of apoptotic mark-ers including p53, Bax and caspase-3 (32), reduces the level of mitochondrial dysfunctionand lipid pero-xidation (13, 33), exerts high superoxide and NO scavenging activities (34) and therapeutic potential against chronic stress and glioma by reducing oxide-tive damage (8, 35). Here, CASP3 is linked to central nervous system cancer.