We have recently shown that rosiglitazone-induced PPAR-γ activation is able to ameliorate disease characteristics in the rat model of preeclampsia via its downstream target heme oxygenase-1 (HO-1), an enzyme which produces carbon monoxide (CO, a potent vasodilator) and bilirubin, an antioxidant [14, 15]. The gene discussed is HMOX1; the disease is preeclampsia.