Accordingly, a recent study that analyzed the suppressive function and expression of the dopaminergic machinery in Tregs obtained from MS patients or from healthy controls found that DAR5, as well as TH, were up-regulated in Tregs from untreated MS patients when compared with those from healthy controls; however, both TH and DAR5 were down-regulated when Tregs were obtained from IFN-β-treated MS patients (66). This evidence concerns the gene IFNB1 and myeloid sarcoma.