INS and type 1 diabetes mellitus: As the stimulation of NO synthesis by either estriol or progesterone resulted in the control of hyperglycemia through insulin synthesis, it could be inferred that T1DM was not only caused by the destruction of pancreatic β cells, but a T1BDM like condition due to environmental stress was also present in these animals due to the systemic presence of dermcidin (10), a potent inhibitor of all known forms of nitric oxide synthases (16).