Furthermore it has also been reported that T1BDM occurred as a major form of T1DM in many parts of the world due to the dermcidin induced inhibition of glucose uptake, rather than to the destruction of the pancreatic β cells, where glucose has an essential role both in the synthesis and secretion of insulin for the control of hyperglycemia (13, 14) both in the pancreatic β cells (13) as well as in the hepatocytes in the liver (15). This evidence concerns the gene INS and type 1 diabetes mellitus.