This conclusion was drawn from the results that demonstrated the use of both estrogen (particularly estriol) and progesterone in alloxan induced T1DM in the animal model effectively controlled hyperglycemia through the hepatic synthesis of insulin due to the stimulation of NO synthesis mediated through the activation of the estrogen or progesterone receptors on the cell surface as reported before (18, 20). The gene discussed is PGR; the disease is type 1 diabetes mellitus.