As 20% of the menopausic women are reported to develop T1DM (3), and as the occurrence of menopause in women resulted in the permanent cessation of ovarian synthesis of both estrogens and progesterons, investigations were carried out to determine the role of both estrogens and progesterons on the insulin synthesis through the stimulation of NO synthesis in the liver cells in alloxan treated mice where the pancreatic β cells were destroyed which consequently resulted in overt hyperglycemia due to the inhibition of Insulin synthesis. This evidence concerns the gene INS and Hyperglycemia.