In addition, HIF-1α regulates self-renewal of APL leukemic blasts, which is coherent with the role of HIF factors in regulating stem cell maintenance in other hematopoietic contexts (Takubo et al, 2010; Wang et al, 2011; Zhang et al, 2012; Rouault-Pierre et al, 2013). Here, HIF1A is linked to acute promyelocytic leukemia.