Moreover, HIF-1α inhibition also synergized with ATRA in promoting leukemia de-bulking (Fig 4I), therefore suggesting that a strong inhibition of HIF-1α may cooperate with ATRA not only to blunt the leukemia-initiating capacity of APL cells, but also their in vivo survival and/or differentiation. The gene discussed is HIF1A; the disease is leukemia.