Ex vivo APL blasts electroporation with EZN-2968 led to significant impairment in the expression of HIF-1α and HIF-target genes (Fig 4C) and inhibited basal and SDF-1-directed cell migration, CFU-L formation and leukemia involvement in peripheral blood (Fig 4D-F), leading to increased mice survival (Fig 4G). The gene discussed is HIF1A; the disease is acute promyelocytic leukemia.