To gain a better understanding of the direct role of HIF-1α in human APL, a list of bona fide HIF-1α target genes was constructed based on current literature (Wenger et al, 2005) by selecting HIF-1α targets validated in multiple experimental settings and provided with functional HIF-1α binding sites (Supplementary Table S1). This evidence concerns the gene HIF1A and acute promyelocytic leukemia.