For example, the VEGF and FGF/FGFR pathways have been shown to act synergistically in promoting tumor angiogenesis 26, while an upregulation of bFGF was recently proposed as one of the mechanisms by which the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway mediates tumor angiogenesis in NSCLC 27. This evidence concerns the gene STAT3 and non-small cell lung carcinoma.