FGFR1 and non-small cell lung carcinoma: In the aforementioned DFCI study, in which 21% of squamous tumors exhibited FGFR1 amplification, cell growth inhibition of an NSCLC line with focal FGFR1 amplification was demonstrated via FGFR1-specific small hairpin ribonucleic acids (shRNAs) or small molecule inhibitors 15.