In particular, very low-density lipoprotein (VLDL) particle concentration (VLDL-P) and low-density lipoprotein (LDL) particle concentration (LDL-P) are increased and HDL particle concentration (HDL-P) is decreased in patients with insulin resistance or T2DM compared with individuals who have normal insulin sensitivity [2]. The gene discussed is INS; the disease is type 2 diabetes mellitus.